Hemoglobin C crystals are seen in individuals who are homozygous for the abnormal hemoglobin C gene which causes hemoglobin C disease. The trait is more common in those of African descent. The disease can cause mild hemolytic anemia, splenomegaly, jaundice, and pigmented gallstones.
Appearance
Hemoglobin C is less soluble than normal hemoglobin which can cause it to crystallize. These crystals stain densely red as the hemoglobin is concentrated to a rhomboid rod-shaped area.
