Toxic granulation is seen most often in bacterial infection and may be accompanied by a left shift with dohle bodies or vacuolization.
Appearance
Toxic granulation refers to a neutrophil with coarse, dark blue granules filling the cytoplasm. These granules are similar in appearance and function to the primary granules seen in promyelocytes.
Lookalikes
The larger toxic granules can be confused for those seen in eosinophils, especially if the staining is poor. However, eosinophil granules are coarser with a reddish-orange color instead of dark blue.
Gallery
