True Pelger-Huet neutrophils are an inherited disorder and completely benign.
Pseudo Pelger-Huet, or pelgeroid cells, can be caused by certain medications or Myelodysplastic Syndromes.
Pelger-Huet Appearance
With Pelger-Huet anomaly, the majority of neutrophils will be hyposegmented. Bilobed neutrophils are described as having a characteristic pince-nez shape (a particular style of glasses).

Pelgeroid Appearance
Neutrophils with a pelgeroid appearance have a hyposegmented nucleus which can be bilobed or monolobed.

Lookalikes
Monolobed neutrophils may be mistaken as myelocytes if care is not taken. However, chromatin is notably more condensed than that of myelocytes. The cytoplasm also lacks those primary azurophilic granules.
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