With Pelger-Huet anomaly, the majority of neutrophils will be hyposegmented. Bilobed neutrophils are described as having a characteristic pince-nez shape (a particular style of glasses).

Neutrophils with a pelgeroid appearance have a hyposegmented nucleus which can be bilobed or monolobed.

Monolobed neutrophils may be mistaken as myelocytes if care is not taken. However, chromatin is notably more condensed than that of myelocytes. The cytoplasm also lacks those primary azurophilic granules.